| 26/09/2020 | 20:00 | K.Patro Eisden Maasmech. | K.SK. Heist A | 2-2 |
| 3/10/2020 | 20:00 | K.SK. Heist A | Olympic Club Charleroi | |
| 11/10/2020 | 15:00 | Francs Borains | K.SK. Heist A | |
| 17/10/2020 | 20:00 | K.SK. Heist A | K.SV.Roeselare | |
| 24/10/2020 | 19:30 | VV.Thes Sport Tessenderlo A | K.SK. Heist A | |
| 31/10/2020 | 20:00 | K.SK. Heist A | R.FC.de Liège A | |
| 7/11/2020 | 20:00 | K.SK. Heist A | URSL Visé | |
| 15/11/2020 | 20:00 | K.Rupel Boom FC. | K.SK. Heist A | |
| 21/11/2020 | 20:00 | K.SK. Heist A | La Louvière Centre A | |
| 29/11/2020 | 15:00 | R.Knokke FC. | K.SK. Heist A | |
| 5/12/2020 | 19:30 | FC.V.Dender E.H. | K.SK. Heist A | |
| 12/12/2020 | 20:00 | K.SK. Heist A | FC MU Izegem-Ingelmunster A | |
| 19/12/2020 | 19:30 | K.FC.Dessel Sport | K.SK. Heist A | |
| 9/01/2021 | 20:00 | K.SK. Heist A | K.VK.Tienen B | |
| 17/01/2021 | 15:00 | K.Sint-Eloois-Winkel Sp. A | K.SK. Heist A | |
| 23/01/2021 | 20:00 | K.SK. Heist A | K.Rupel Boom FC. | |
| 31/01/2021 | 15:00 | R.FC.de Liège A | K.SK. Heist A | |
| 6/02/2021 | 20:00 | K.SK. Heist A | Francs Borains | |
| 13/02/2021 | 20:00 | La Louvière Centre A | K.SK. Heist A | |
| 20/02/2021 | 20:00 | K.SK. Heist A | R.Knokke FC. | |
| 28/02/2021 | 15:00 | K.VK.Tienen B | K.SK. Heist A | |
| 6/03/2021 | 20:00 | K.SK. Heist A | K.Patro Eisden Maasmech. | |
| 13/03/2021 | 20:00 | FC MU Izegem-Ingelmunster A | K.SK. Heist A | |
| 20/03/2021 | 20:00 | K.SK. Heist A | VV.Thes Sport Tessenderlo A | |
| 28/03/2021 | 15:00 | URSL Visé | K.SK. Heist A | |
| 10/04/2021 | 20:00 | K.SK. Heist A | K.FC.Dessel Sport | |
| 18/04/2021 | 15:00 | K.SV.Roeselare | K.SK. Heist A | |
| 24/04/2021 | 20:00 | K.SK. Heist A | FC.V.Dender E.H. | |
| 1/05/2021 | 20:00 | K.SK. Heist A | K.Sint-Eloois-Winkel Sp. A | |
| 8/05/2021 | 20:00 | Olympic Club Charleroi | K.SK. Heist A |