| 25/09/2020 | 20:30 | K.SK Heist B | K.Patro Eisden Maasmech. | 2-2 |
| 2/10/2020 | 19:30 | Olympic Club Charleroi | K.SK Heist B | 5-4 |
| 9/10/2020 | 20:30 | K.SK Heist B | Francs Borains | 5-4 |
| 19/10/2020 | 19:30 | K.SV.Roeselare | K.SK Heist B | |
| 23/10/2020 | 20:30 | K.SK Heist B | VV.Thes Sport Tessenderlo A | |
| 30/10/2020 | 20:00 | R.FC.de Liège | K.SK Heist B | |
| 6/11/2020 | 19:30 | URSL Visé | K.SK Heist B | |
| 13/11/2020 | 20:30 | K.SK Heist B | K.Rupel Boom FC. | |
| 20/11/2020 | 20:00 | La Louvière Centre | K.SK Heist B | |
| 27/11/2020 | 20:30 | K.SK Heist B | R.Knokke FC. | |
| 4/12/2020 | 20:30 | K.SK Heist B | FC.V.Dender E.H. | |
| 11/12/2020 | 20:15 | FC MU Izegem-Ingelmunster A | K.SK Heist B | |
| 18/12/2020 | 20:30 | K.SK Heist B | K.FC.Dessel Sport | |
| 8/01/2021 | 20:15 | K.VK.Tienen | K.SK Heist B | |
| 15/01/2021 | 20:30 | K.SK Heist B | K.Sint-Eloois-Winkel Sp. | |
| 25/01/2021 | 20:00 | K.Rupel Boom FC. | K.SK Heist B | |
| 29/01/2021 | 20:30 | K.SK Heist B | R.FC.de Liège | |
| 8/02/2021 | 20:30 | Francs Borains | K.SK Heist B | |
| 12/02/2021 | 20:30 | K.SK Heist B | La Louvière Centre | |
| 22/02/2021 | 20:00 | R.Knokke FC. | K.SK Heist B | |
| 26/02/2021 | 20:30 | K.SK Heist B | K.VK.Tienen | |
| 8/03/2021 | 19:30 | K.Patro Eisden Maasmech. | K.SK Heist B | |
| 12/03/2021 | 20:30 | K.SK Heist B | FC MU Izegem-Ingelmunster A | |
| 19/03/2021 | 20:00 | VV.Thes Sport Tessenderlo A | K.SK Heist B | |
| 26/03/2021 | 20:30 | K.SK Heist B | URSL Visé | |
| 9/04/2021 | 20:00 | K.FC.Dessel Sport | K.SK Heist B | |
| 16/04/2021 | 20:30 | K.SK Heist B | K.SV.Roeselare | |
| 26/04/2021 | 20:00 | FC.V.Dender E.H. | K.SK Heist B | |
| 30/04/2021 | 20:00 | K.Sint-Eloois-Winkel Sp. | K.SK Heist B | |
| 7/05/2021 | 20:30 | K.SK Heist B | Olympic Club Charleroi |